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Glossary

  • Chloroplast DNA

    constitutes the chloroplast genome: transmitted only by mothers, very little variation over time, makes it possible to track maternal lineages

  • Mitochondrial DNA

    constitutes the mitochondrial genome: transmitted only by mothers, very little variation over time, makes it possible to track maternal lineages

  • Apoptosis

    ability to induce programmed cell death

  • Blood-brain barrier Barrier (BBB)

    barrier between the peripheral blood and central nervous system

  • Endothelial cell

    specialized cell that is part of the composition of blood vessels

  • NK cells

    class of immune cells with a cytotoxic function

  • Chloroplasts

    cellular compartments in plants responsible for photosynthesis. Transmitted only by mothers.

  • Cytoadherence

    ability to adhere to cells, particularly endothelial cells

  • Epitope

    immunogenic protein fragment

  • Phylogenetic Study

    Development study of the genetic evolution of a living being (micro-organism, plant, animal)

  • Hepatocyte

    specialized liver cells

  • Hepatoma

    malignant liver tissue cell

  • Isolate

    a parasite strain isolated from the field

  • Deep microvascular beds

    small blood vessels in the deep tissues, in particular the brain

  • Mitochondria

    cellular structures in animals, responsible for energy synthesis. Transmitted only by mothers.

  • Pathogenicity

    ability to induce disease

  • PBMC

    peripheral blood mononuclear cells

  • Phenotypic

    related to the structure

  • Phylogeography

    analysis that also takes into account the geographical distribution of the lines studied

  • Primatology

    study of the species of the order of primates

  • Primatologist

    someone who specializes in the science of primates.

  • CTL response

    cytotoxic immune response

  • Reservoir

    animal species that hosts a pathogen over a long period

  • Trypanosomiasis

    sleeping sickness

Public Health

The CIRMF is the leading national laboratory for the diagnosis of viral hemorrhagic fevers. The CIRMF’s activities include:

  • Diagnosis of suspected cases during outbreaks of Ebola hemorrhagic fever
  • Development of new diagnostic methods for Ebola infection
  • Surveillance of animal mortality
  • Epidemic outbreak response

Today, the CIRMF has over 2000 samples of various origins, and makes its biological research centre accessible to the international scientific community.
The Centre participates in field interventions during epidemics (Ebola, dengue fever and chikungunya) alongside the national and/or international health authorities. It also participates in surveys of endemic viral hepatitis and AIDS in collaboration with the Ministry of Health. The Medical Analysis Laboratory of the CIRMF performs all types of analyses in the fields of parasitology, virology, haematology, biochemistry, immunology and bacteriology, primarily for the population of the province of Upper Ogooué. Finally, the CIRMF, through its diagnosis and research laboratory, participates in public health surveillance on sickle cell disease in collaboration with the responsible authorities.